Research

“Future research needs to focus not only on the biological markers of autism but also include data about functioning, participation, and environmental barriers and facilitators.”
Dr. Olaf Kraus de Camargo // Developmental Pediatrician

MacART is laying the foundation for creating a systematic way of linking scientific research on autism at McMaster University to clinical practice at McMaster Children’s Hospital.

The physical proximity of McMaster Children’s Hospital, Hamilton Health Sciences, and McMaster University has a number of characteristics that provides the rare opportunity for collaborative research. Taking advantage of existing university and clinical infrastructure and cross-appointments for clinicians at the university, autism experts from these organizations are coming together to integrate autism research into clinical practice.

The focus of MacART members’ research is in the areas of basic science, clinical practice, clinical research, epidemiology and statistical modelling, knowledge translation and exchange, and social science research. By promoting the collaboration of stakeholders across disciplines, MacART is reducing barriers to implementing research in clinical practice, with the goal of advancing autism care through meaningful research.

Learn more about our research HERE.

Education

MacART members are now supervising more than 50 research trainees at the undergraduate, graduate, and postgraduate levels, and are engaged in the mentoring of junior and intermediate faculty members.

In the future, we intend to establish research and clinical training programs for students in McMaster’s undergraduate medical, health sciences, and psychology programs, and for residents and fellows in Pediatrics and Psychiatry.

By training and mentoring emerging researchers and practitioners, we will help to solidify their understanding of and commitment to using basic science to inform their clinical practice, and to use their clinical experience to help formulate research questions. It is our belief that involving these learners in MacART educational activities will promote their use of practices that advance autism care through meaningful research.

Community

“Our scientists are working collaboratively with local clinicians to generate the evidence needed to improve autism services. This symposium is a great example of McMaster’s community engagement efforts.”
Dr. Patrick Deane // President & Vice-Chancellor // McMaster University

The community engagement component of MacART strives to work with stakeholders and involve them as partners in every step of the research process. By doing so, the questions that drive research begin to change. They become more meaningful because they address the real day-to-day challenges faced by children and their families, and the clinicians supporting them.

MacART aims to increase participation and involvement of members of the McMaster and Hamilton communities in the research process. With community members driving the research, new and relevant knowledge can be produced to bridge the research-to-practice gap in autism and advance autism care through meaningful research.

Policy

“People whose lives are connected to the challenge of autism can share knowledge – from clinicians to educators to parents – and what an amazing opportunity that is. We have a real opportunity to translate challenges into research, and research into practice that will help families living with Autism.”
Rob MacIsaac // President & CEO // Hamilton Health Sciences

Policies should be created using the best available evidence that make positive impacts on the lives of Autistic individuals, along with their families.

MacART’s founder, Dr. Stelios Georgiades, serves on both federal and provincial advisory committees about Autism supports/service funding. Along with the wide-ranging expertise of its many autism experts, MacART is set to act as a highly credible source of evidence-based information to influence and inform public policy about the provision and funding of autism diagnosis, services, and family supports.

MacART will continue to find ways to collaborate with policymakers to both learn more about the policymaking process, and to contribute our expertise and knowledge to inform policymaking, in order to advance Autism care through meaningful research.

MacART members at POND Science Day

Research

“Future research needs to focus not only on the biological markers of autism but also include data about functioning, participation, and environmental barriers and facilitators.”
Dr. Olaf Kraus de Camargo // Developmental Pediatrician

MacART is laying the foundation for creating a systematic way of linking scientific research on autism at McMaster University to clinical practice at McMaster Children’s Hospital.

The physical proximity of McMaster Children’s Hospital, Hamilton Health Sciences, and McMaster University has a number of characteristics that provides the rare opportunity for collaborative research. Taking advantage of existing university and clinical infrastructure and cross-appointments for clinicians at the university, autism experts from these organizations are coming together to integrate autism research into clinical practice.

The focus of MacART members’ research is in the areas of basic science, clinical practice, clinical research, epidemiology and statistical modelling, knowledge translation and exchange, and social science research. By promoting the collaboration of stakeholders across disciplines, MacART is reducing barriers to implementing research in clinical practice, with the goal of advancing autism care through meaningful research.

Learn more about our research HERE.

Education

MacART members are now supervising more than 50 research trainees at the undergraduate, graduate, and postgraduate levels, and are engaged in the mentoring of junior and intermediate faculty members.

In the future, we intend to establish research and clinical training programs for students in McMaster’s undergraduate medical, health sciences, and psychology programs, and for residents and fellows in Pediatrics and Psychiatry.

By training and mentoring emerging researchers and practitioners, we will help to solidify their understanding of and commitment to using basic science to inform their clinical practice, and to use their clinical experience to help formulate research questions. It is our belief that involving these learners in MacART educational activities will promote their use of practices that advance autism care through meaningful research.

Community

“Our scientists are working collaboratively with local clinicians to generate the evidence needed to improve autism services. This symposium is a great example of McMaster’s community engagement efforts.”
Dr. Patrick Deane // President & Vice-Chancellor // McMaster University

The community engagement component of MacART strives to work with stakeholders and involve them as partners in every step of the research process. By doing so, the questions that drive research begin to change. They become more meaningful because they address the real day-to-day challenges faced by children and their families, and the clinicians supporting them.

MacART aims to increase participation and involvement of members of the McMaster and Hamilton communities in the research process. With community members driving the research, new and relevant knowledge can be produced to bridge the research-to-practice gap in autism and advance autism care through meaningful research.

Policy

“People whose lives are connected to the challenge of autism can share knowledge – from clinicians to educators to parents – and what an amazing opportunity that is. We have a real opportunity to translate challenges into research, and research into practice that will help families living with Autism.”
Rob MacIsaac // President & CEO // Hamilton Health Sciences

Policies should be created using the best available evidence that make positive impacts on the lives of Autistic individuals, along with their families.

MacART’s founder, Dr. Stelios Georgiades, serves on both federal and provincial advisory committees about Autism supports/service funding. Along with the wide-ranging expertise of its many autism experts, MacART is set to act as a highly credible source of evidence-based information to influence and inform public policy about the provision and funding of autism diagnosis, services, and family supports.

MacART will continue to find ways to collaborate with policymakers to both learn more about the policymaking process, and to contribute our expertise and knowledge to inform policymaking, in order to advance Autism care through meaningful research.

Various MacART members were on hand at POND Science Day on November 30^th – a workshop to share recent findings, network with colleagues, and help set the research agenda for the project’s renewal.

Jane Foster gave an overview of mouse work that looks at how microbiota and the immune system influence brain structure and behaviour. Some key points include:

MRI analysis of germ-free mice lacking exposure to all microbes revealed global changes in brain structure that are not restored if reconstituted in early adolescence.
Gene-environment interactions influence the composition of gut microbiota – the Foster lab is working to determine how these interactions influence brain regions that regulate social behaviour.
Gene-environment interactions influence the composition of gut microbiota – the Foster lab has identified specific gut bacteria that influence anxiety-like behaviour in mice.

Jane also gave an update on the immunophenotyping platform for POND. Four sites are now collecting blood samples to examine inflammatory markers and immune cells in peripheral blood. This work will help identify biological differences in individuals with neurodevelopment disorders.

It is exciting to see such cutting-edge research being done by our members!